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TitleDiscovery of orally active pyrazoloquinolines as potent PDE10 inhibitors for the management of schizophrenia.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 22, Page 235-239, Year 2012
Publish dateNov 4, 2011 (structure data deposition date)
AuthorsYang, S.W. / Smotryski, J. / McElroy, W.T. / Tan, Z. / Ho, G. / Tulshian, D. / Greenlee, W.J. / Guzzi, M. / Zhang, X. / Mullins, D. ...Yang, S.W. / Smotryski, J. / McElroy, W.T. / Tan, Z. / Ho, G. / Tulshian, D. / Greenlee, W.J. / Guzzi, M. / Zhang, X. / Mullins, D. / Xiao, L. / Hruza, A. / Chan, T.M. / Rindgen, D. / Bleickardt, C. / Hodgson, R.
External linksBioorg. Med. Chem. Lett. / PubMed:22142545
MethodsX-ray diffraction
Resolution2.28 Å
Structure data

PDB-3ui7:
Discovery of orally active pyrazoloquinoline as a potent PDE10 inhibitor for the management of schizophrenia
Method: X-RAY DIFFRACTION / Resolution: 2.28 Å

Chemicals

ChemComp-C1L:
6-methoxy-3,8-dimethyl-4-(morpholin-4-ylmethyl)-1H-pyrazolo[3,4-b]quinoline

ChemComp-MG:
Unknown entry

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE/HYDROLASE INHIBITOR / INHIBITOR COMPLEX / HYDROLASE / ZN BINDING / MG BINDING / HYDROLASE-HYDROLASE INHIBITOR complex

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