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| Title | Pyridone methylsulfone hydroxamate LpxC inhibitors for the treatment of serious gram-negative infections. |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 55, Page 1662-1670, Year 2012 |
| Publish date | Nov 3, 2011 (structure data deposition date) |
 Authors | Montgomery, J.I. / Brown, M.F. / Reilly, U. / Price, L.M. / Abramite, J.A. / Arcari, J. / Barham, R. / Che, Y. / Chen, J.M. / Chung, S.W. ...Montgomery, J.I. / Brown, M.F. / Reilly, U. / Price, L.M. / Abramite, J.A. / Arcari, J. / Barham, R. / Che, Y. / Chen, J.M. / Chung, S.W. / Collantes, E.M. / Desbonnet, C. / Doroski, M. / Doty, J. / Engtrakul, J.J. / Harris, T.M. / Huband, M. / Knafels, J.D. / Leach, K.L. / Liu, S. / Marfat, A. / McAllister, L. / McElroy, E. / Menard, C.A. / Mitton-Fry, M. / Mullins, L. / Noe, M.C. / O'Donnell, J. / Oliver, R. / Penzien, J. / Plummer, M. / Shanmugasundaram, V. / Thoma, C. / Tomaras, A.P. / Uccello, D.P. / Vaz, A. / Wishka, D.G. |
 External links | J. Med. Chem. / PubMed:22257165 |
| Methods | X-ray diffraction |
| Resolution | 1.26 Å |
| Structure data |  PDB-3uhm: |
| Chemicals |  ChemComp-ZN:  ChemComp-RFN:  ChemComp-GAI:  ChemComp-EDO:  ChemComp-HOH: |
| Source |
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 Keywords | Hydrolase/Hydrolase inhibitor / Amidohydrolases / Anti-Bacterial Agents / Bacteria / Catalytic Domain / Drug Design / Enzyme Inhibitors / Gram Negative / Hydrolase-Hydrolase inhibitor complex |
pseudomonas aeruginosa (bacteria)