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Structure paper

TitleDiscovery of LFF571: an investigational agent for Clostridium difficile infection.
Journal, issue, pagesJ. Med. Chem., Vol. 55, Page 2376-2387, Year 2012
Publish dateOct 4, 2011 (structure data deposition date)
AuthorsLaMarche, M.J. / Leeds, J.A. / Amaral, A. / Brewer, J.T. / Bushell, S.M. / Deng, G. / Dewhurst, J.M. / Ding, J. / Dzink-Fox, J. / Gamber, G. ...LaMarche, M.J. / Leeds, J.A. / Amaral, A. / Brewer, J.T. / Bushell, S.M. / Deng, G. / Dewhurst, J.M. / Ding, J. / Dzink-Fox, J. / Gamber, G. / Jain, A. / Lee, K. / Lee, L. / Lister, T. / McKenney, D. / Mullin, S. / Osborne, C. / Palestrant, D. / Patane, M.A. / Rann, E.M. / Sachdeva, M. / Shao, J. / Tiamfook, S. / Trzasko, A. / Whitehead, L. / Yifru, A. / Yu, D. / Yan, W. / Zhu, Q.
External linksJ. Med. Chem. / PubMed:22315981
MethodsX-ray diffraction
Resolution2.7 Å
Structure data

PDB-3u2q:
EF-Tu (Escherichia coli) in complex with NVP-LFF571
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • escherichia coli (E. coli)
Keywordstranslation factor/antibiotic / translation factor-antibiotic complex

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