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-Structure paper
Title | Increased Diels-Alderase activity through backbone remodeling guided by Foldit players. |
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Journal, issue, pages | Nat. Biotechnol., Vol. 30, Page 190-192, Year 2012 |
Publish date | Sep 29, 2011 (structure data deposition date) |
Authors | Eiben, C.B. / Siegel, J.B. / Bale, J.B. / Cooper, S. / Khatib, F. / Shen, B.W. / Players, F. / Stoddard, B.L. / Popovic, Z. / Baker, D. |
External links | Nat. Biotechnol. / PubMed:22267011 |
Methods | X-ray diffraction |
Resolution | 2.6 Å |
Structure data | PDB-3u0s: |
Chemicals | ChemComp-EPE: ChemComp-GOL: ChemComp-SO4: ChemComp-NA: ChemComp-HOH: |
Source |
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Keywords | DE NOVO PROTEIN / HYDROLASE / protein engineering / computer-aided design / computationally-directed design / multiplayer online gaming / crowdsourcing / Foldit / Diels-Alder / enzyme design / active site redesign / substrate specificity / beta-propeller / helix-loop-helix / loop remodel |