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Title | A new phenylalanine derivative acts as an antagonist at the AMPA receptor GluA2 and introduces partial domain closure: synthesis, resolution, pharmacology, and crystal structure |
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Journal, issue, pages | J. Med. Chem., Vol. 54, Page 7289-7298, Year 2011 |
Publish date | Sep 27, 2011 (structure data deposition date) |
![]() | Szymanska, E. / Frydenvang, K. / Contreras-Sanz, A. / Pickering, D.S. / Frola, E. / Serafimoska, Z. / Nielsen, B. / Kastrup, J.S. / Johansen, T.N. |
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Methods | X-ray diffraction |
Resolution | 1.9 Å |
Structure data | ![]() PDB-3tza: |
Chemicals | ![]() ChemComp-TZG: ![]() ChemComp-SO4: ![]() ChemComp-HOH: |
Source |
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![]() | MEMBRANE PROTEIN / AMPA receptor ligand-binding domain / GluA2-S1S2J / antagonist |