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Title | Pyrazolopyridine Inhibitors of B-Raf(V600E). Part 1: The Development of Selective, Orally Bioavailable, and Efficacious Inhibitors. |
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Journal, issue, pages | ACS Med Chem Lett, Vol. 2, Page 342-347, Year 2011 |
Publish date | Sep 19, 2011 (structure data deposition date) |
Authors | Wenglowsky, S. / Ren, L. / Ahrendt, K.A. / Laird, E.R. / Aliagas, I. / Alicke, B. / Buckmelter, A.J. / Choo, E.F. / Dinkel, V. / Feng, B. ...Wenglowsky, S. / Ren, L. / Ahrendt, K.A. / Laird, E.R. / Aliagas, I. / Alicke, B. / Buckmelter, A.J. / Choo, E.F. / Dinkel, V. / Feng, B. / Gloor, S.L. / Gould, S.E. / Gross, S. / Gunzner-Toste, J. / Hansen, J.D. / Hatzivassiliou, G. / Liu, B. / Malesky, K. / Mathieu, S. / Newhouse, B. / Raddatz, N.J. / Ran, Y. / Rana, S. / Randolph, N. / Risom, T. / Rudolph, J. / Savage, S. / Selby, L.T. / Shrag, M. / Song, K. / Sturgis, H.L. / Voegtli, W.C. / Wen, Z. / Willis, B.S. / Woessner, R.D. / Wu, W.I. / Young, W.B. / Grina, J. |
External links | ACS Med Chem Lett / PubMed:24900315 |
Methods | X-ray diffraction |
Resolution | 3.3 - 3.4 Å |
Structure data | PDB-3tv4: PDB-3tv6: |
Chemicals | ChemComp-TV4: ChemComp-B0R: |
Source |
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Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / Kinase / Kinase Inhibitor / Transferase / Ras / C-Raf / MEK / TRANSFERASE-TRANSFERASE INHIBITOR complex / B-Raf |