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Structure paper

TitleStructural insight into the molecular basis of polyextremophilicity of short-chain alcohol dehydrogenase from the hyperthermophilic archaeon Thermococcus sibiricus.
Journal, issue, pagesBiochimie, Vol. 94, Page 2628-2638, Year 2012
Publish dateSep 1, 2011 (structure data deposition date)
AuthorsBezsudnova, E.Y. / Boyko, K.M. / Polyakov, K.M. / Dorovatovskiy, P.V. / Stekhanova, T.N. / Gumerov, V.M. / Ravin, N.V. / Skryabin, K.G. / Kovalchuk, M.V. / Popov, V.O.
External linksBiochimie / PubMed:22885278
MethodsX-ray diffraction
Resolution1.68 Å
Structure data

PDB-3tn7:
Crystal structure of short-chain alcohol dehydrogenase from hyperthermophilic archaeon Thermococcus sibiricus complexed with 5-hydroxy-NADP
Method: X-RAY DIFFRACTION / Resolution: 1.68 Å

Chemicals

ChemComp-NJP:
5-hydroxy-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • thermococcus sibiricus (archaea)
KeywordsOXIDOREDUCTASE / NADP-dependent dehydrogenase / short-chain dehydrogenase / 5-hydroxy-NADP / thermophile / archaea / Rossmann Fold / oxidation of alcohols and reductions of ketones and aldehydes

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