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Structure paper

TitleStructural basis of APH(3')-IIIa-mediated resistance to N1-substituted aminoglycoside antibiotics.
Journal, issue, pagesAntimicrob. Agents Chemother., Vol. 53, Page 3049-3055, Year 2009
Publish dateAug 30, 2011 (structure data deposition date)
AuthorsFong, D.H. / Berghuis, A.M.
External linksAntimicrob. Agents Chemother. / PubMed:19433564
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-3tm0:
Crystal Structure of 3',5"-Aminoglycoside Phosphotransferase Type IIIa AMPPNP Butirosin A Complex
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-ANP:
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER / AMP-PNP, energy-carrying molecule analogue*YM

ChemComp-B31:
(2S)-4-amino-N-[(1R,2S,3R,4R,5S)-5-amino-4-[(2,6-diamino-2,6-dideoxy-alpha-D-glucopyranosyl)oxy]-2-hydroxy-3-(beta-D-xylofuranosyloxy)cyclohexyl]-2-hydroxybutanamide

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • enterococcus faecalis (bacteria)
KeywordsTRANSFERASE/ANTIBIOTIC / protein kinase / phosphorylation / TRANSFERASE-ANTIBIOTIC complex

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