+Search query
-Structure paper
Title | Pharmacological characterization, structural studies, and in vivo activities of anti-chagas disease lead compounds derived from tipifarnib. |
---|---|
Journal, issue, pages | Antimicrob. Agents Chemother., Vol. 56, Page 4914-4921, Year 2012 |
Publish date | Aug 20, 2011 (structure data deposition date) |
![]() | Buckner, F.S. / Bahia, M.T. / Suryadevara, P.K. / White, K.L. / Shackleford, D.M. / Chennamaneni, N.K. / Hulverson, M.A. / Laydbak, J.U. / Chatelain, E. / Scandale, I. ...Buckner, F.S. / Bahia, M.T. / Suryadevara, P.K. / White, K.L. / Shackleford, D.M. / Chennamaneni, N.K. / Hulverson, M.A. / Laydbak, J.U. / Chatelain, E. / Scandale, I. / Verlinde, C.L. / Charman, S.A. / Lepesheva, G.I. / Gelb, M.H. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 2.05 Å |
Structure data | ![]() PDB-3tik: |
Chemicals | ![]() ChemComp-HEM: ![]() ChemComp-JKF: ![]() ChemComp-HOH: |
Source |
|
![]() | OXIDOREDUCTASE / STEROL 14-ALPHA DEMETHYLASE / CYP51 / HEME / MONOOXYGENASE / STEROL BIOSYNTHESIS / Cytochrome P450 fold / cytochrome P450 reductase / endoplasmic reticulum membrane |