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-Structure paper
| Title | Discovery of a Potent and Orally Bioavailable Benzolactam-Derived Inhibitor of Polo-Like Kinase 1 (MLN0905). |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 55, Page 197-208, Year 2012 |
| Publish date | Aug 18, 2011 (structure data deposition date) |
 Authors | Duffey, M.O. / Vos, T.J. / Adams, R. / Alley, J. / Anthony, J. / Barrett, C. / Bharathan, I. / Bowman, D. / Bump, N.J. / Chau, R. ...Duffey, M.O. / Vos, T.J. / Adams, R. / Alley, J. / Anthony, J. / Barrett, C. / Bharathan, I. / Bowman, D. / Bump, N.J. / Chau, R. / Cullis, C. / Driscoll, D.L. / Elder, A. / Forsyth, N. / Frazer, J. / Guo, J. / Guo, L. / Hyer, M.L. / Janowick, D. / Kulkarni, B. / Lai, S.J. / Lasky, K. / Li, G. / Li, J. / Liao, D. / Little, J. / Peng, B. / Qian, M.G. / Reynolds, D.J. / Rezaei, M. / Scott, M.P. / Sells, T.B. / Shinde, V. / Shi, Q.J. / Sintchak, M.D. / Soucy, F. / Sprott, K.T. / Stroud, S.G. / Nestor, M. / Visiers, I. / Weatherhead, G. / Ye, Y. / D'Amore, N. |
 External links | J. Med. Chem. / PubMed:22070629 |
| Methods | X-ray diffraction |
| Resolution | 2.5 Å |
| Structure data |  PDB-3thb: |
| Chemicals |  ChemComp-ZN:  ChemComp-3TA: |
| Source |
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 Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / kinase domain / TRANSFERASE-TRANSFERASE INHIBITOR complex |
homo sapiens (human)