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| Title | Discovery of 3-hydroxy-4-cyano-isoquinolines as novel, potent, and selective inhibitors of human 11beta-hydroxydehydrogenase 1 (11beta-HSD1) |
|---|---|
| Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 21, Page 6693-6698, Year 2011 |
| Publish date | Aug 16, 2011 (structure data deposition date) |
 Authors | Wu, S.C. / Yoon, D. / Chin, J. / van Kirk, K. / Seethala, R. / Golla, R. / He, B. / Harrity, T. / Kunselman, L.K. / Morgan, N.N. ...Wu, S.C. / Yoon, D. / Chin, J. / van Kirk, K. / Seethala, R. / Golla, R. / He, B. / Harrity, T. / Kunselman, L.K. / Morgan, N.N. / Ponticiello, R.P. / Taylor, J.R. / Zebo, R. / Harper, T.W. / Li, W. / Wang, M. / Zhang, L. / Sleczka, B.G. / Nayeem, A. / Sheriff, S. / Camac, D.M. / Morin, P.E. / Everlof, J.G. / Li, Y.X. / Ferraro, C.A. / Kieltyka, K. / Shou, W. / Vath, M.B. / Zvyaga, T.A. / Gordon, D.A. / Robl, J.A. |
 External links | Bioorg. Med. Chem. Lett. / PubMed:21983444 |
| Methods | X-ray diffraction |
| Resolution | 1.8 Å |
| Structure data |  PDB-3tfq: |
| Chemicals |  ChemComp-NAP:  ChemComp-07M:  ChemComp-GOL:  ChemComp-HOH: |
| Source |
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 Keywords | Oxidoreductase/Oxidoreductase Inhibitor / 11B-HSD1 / SDR / DEHYDROGENASE / HYDROXYSTEROID / INHIBITOR / OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR COMPLEX |
homo sapiens (human)