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TitleSynthesis and biological activity of optimized belactosin C congeners.
Journal, issue, pagesOrg. Biomol. Chem., Vol. 9, Page 7791-7798, Year 2011
Publish dateAug 10, 2011 (structure data deposition date)
AuthorsKorotkov, V.S. / Ludwig, A. / Larionov, O.V. / Lygin, A.V. / Groll, M. / de Meijere, A.
External linksOrg. Biomol. Chem. / PubMed:21946808
MethodsX-ray diffraction
Resolution2.7 Å
Structure data

PDB-3tdd:
Crystal structure of yeast CP in complex with Belactosin C
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-BFO:
benzyl N-[(naphthalen-2-ylmethoxy)carbonyl]-L-alanyl-N~5~-[(2R,3S,4S)-3-formyl-2-hydroxy-4-methylhexanoyl]-L-ornithinate

ChemComp-HOH:
WATER

Source
  • saccharomyces cerevisiae (brewer's yeast)
KeywordsHYDROLASE/HYDROLASE INHIBITOR / ubiquitin / inhibitor / proteasome / drug development / primed substrate binding channel / beta-sandwich flanked by alpha-helices / Hydrolase / HYDROLASE-HYDROLASE INHIBITOR complex

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