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-Structure paper
Title | Imidazo[1,5-a]quinoxalines as irreversible BTK inhibitors for the treatment of rheumatoid arthritis. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 21, Page 6258-6263, Year 2011 |
Publish date | Aug 3, 2011 (structure data deposition date) |
Authors | Kim, K.H. / Maderna, A. / Schnute, M.E. / Hegen, M. / Mohan, S. / Miyashiro, J. / Lin, L. / Li, E. / Keegan, S. / Lussier, J. ...Kim, K.H. / Maderna, A. / Schnute, M.E. / Hegen, M. / Mohan, S. / Miyashiro, J. / Lin, L. / Li, E. / Keegan, S. / Lussier, J. / Wrocklage, C. / Nickerson-Nutter, C.L. / Wittwer, A.J. / Soutter, H. / Caspers, N. / Han, S. / Kurumbail, R. / Dunussi-Joannopoulos, K. / Douhan, J. / Wissner, A. |
External links | Bioorg. Med. Chem. Lett. / PubMed:21958547 |
Methods | X-ray diffraction |
Resolution | 1.65 Å |
Structure data | PDB-3t9t: |
Chemicals | ChemComp-IAQ: ChemComp-GOL: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / kinase domain / alpha/beta / ATP binding / phosphorylation / intracellular / TRANSFERASE-TRANSFERASE INHIBITOR complex |