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Structure paper

TitleA new class of suicide inhibitor blocks nucleotide binding to pyruvate kinase
Journal, issue, pagesTo be Published
Publish dateJul 7, 2011 (structure data deposition date)
AuthorsMorgan, H.P. / Walsh, M. / Blackburn, E.A. / Wear, M.A. / Boxer, M. / Shen, M. / McNae, I.W. / Michels, P.A.M. / Auld, D.S. / Fothergill-Gilmore, L.A. / Walkinshaw, M.D.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.65 Å
Structure data

PDB-3srk:
A new class of suicide inhibitor blocks nucleotide binding to pyruvate kinase
Method: X-RAY DIFFRACTION / Resolution: 2.65 Å

Chemicals

ChemComp-LSA:
1,2-BENZISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE

ChemComp-K:
Unknown entry

ChemComp-PTK:
pyrene-1,3,6,8-tetrasulfonic acid

ChemComp-HOH:
WATER

Source
  • leishmania mexicana (eukaryote)
KeywordsTransferase/Inhibitor / TIM Barrel / Sugar Kinase / Phospho transfer / Phosphenolpyruvate / Transferase-Inhibitor complex

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