+Search query
-Structure paper
Title | Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential. |
---|---|
Journal, issue, pages | J. Med. Chem., Vol. 54, Page 5540-5561, Year 2011 |
Publish date | Jun 13, 2011 (structure data deposition date) |
![]() | Coteron, J.M. / Marco, M. / Esquivias, J. / Deng, X. / White, K.L. / White, J. / Koltun, M. / El Mazouni, F. / Kokkonda, S. / Katneni, K. ...Coteron, J.M. / Marco, M. / Esquivias, J. / Deng, X. / White, K.L. / White, J. / Koltun, M. / El Mazouni, F. / Kokkonda, S. / Katneni, K. / Bhamidipati, R. / Shackleford, D.M. / Angulo-Barturen, I. / Ferrer, S.B. / Jimenez-Diaz, M.B. / Gamo, F.J. / Goldsmith, E.J. / Charman, W.N. / Bathurst, I. / Floyd, D. / Matthews, D. / Burrows, J.N. / Rathod, P.K. / Charman, S.A. / Phillips, M.A. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 2.95 Å |
Structure data | ![]() PDB-3sfk: |
Chemicals | ![]() ChemComp-D67: ![]() ChemComp-FMN: ![]() ChemComp-ORO: ![]() ChemComp-HOH: |
Source |
|
![]() | OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR / alpha beta fold / pyrimidine biosynthesis / flavoprotein / mitochondrion inner membrane / alpha beta barrel oxidoreductase / inhibitor DSM267 / FMN / Plasmodium falciparum membrane mitochondrion / OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex |