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Structure paper

TitleCrystal structures of murine norovirus-1 RNA-dependent RNA polymerase in complex with 2-thiouridine or ribavirin.
Journal, issue, pagesVirology, Vol. 426, Page 143-151, Year 2012
Publish dateJun 13, 2011 (structure data deposition date)
AuthorsAlam, I. / Lee, J.H. / Cho, K.J. / Han, K.R. / Yang, J.M. / Chung, M.S. / Kim, K.H.
External linksVirology / PubMed:22341781
MethodsX-ray diffraction
Resolution2.209 - 2.501 Å
Structure data

PDB-3sfg:
crystal structure of murine norovirus RNA dependent RNA polymerase in complex with 2thiouridine(2TU)
Method: X-RAY DIFFRACTION / Resolution: 2.209 Å

PDB-3sfu:
crystal structure of murine norovirus RNA dependent RNA polymerase in complex with ribavirin
Method: X-RAY DIFFRACTION / Resolution: 2.501 Å

Chemicals

ChemComp-2TU:
1-(beta-D-ribofuranosyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-RBV:
1-(beta-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxamide / medication, antivirus*YM

Source
  • murine norovirus 1
KeywordsTRANSFERASE / right hand conformation / POLYMERASE / RNA binding / Right handed fold / VIRAL REPLICATION ENZYME

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