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Title | Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors. |
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Journal, issue, pages | Bioorg. Med. Chem., Vol. 19, Page 4626-4634, Year 2011 |
Publish date | Jun 13, 2011 (structure data deposition date) |
![]() | Whitehead, L. / Dobler, M.R. / Radetich, B. / Zhu, Y. / Atadja, P.W. / Claiborne, T. / Grob, J.E. / McRiner, A. / Pancost, M.R. / Patnaik, A. ...Whitehead, L. / Dobler, M.R. / Radetich, B. / Zhu, Y. / Atadja, P.W. / Claiborne, T. / Grob, J.E. / McRiner, A. / Pancost, M.R. / Patnaik, A. / Shao, W. / Shultz, M. / Tichkule, R. / Tommasi, R.A. / Vash, B. / Wang, P. / Stams, T. |
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Methods | X-ray diffraction |
Resolution | 2 - 2.7 Å |
Structure data | ![]() PDB-3sff: ![]() PDB-3sfh: |
Chemicals | ![]() ChemComp-0DI: ![]() ChemComp-K: ![]() ChemComp-ZN: ![]() ChemComp-HOH: ![]() ChemComp-ACT: ![]() ChemComp-1DI: |
Source |
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![]() | HYDROLASE/HYDROLASE INHIBITOR / deacetylase / NVP-LCI785 / HYDROLASE-HYDROLASE INHIBITOR complex |