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TitleStructures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001.
Journal, issue, pagesNature, Vol. 482, Page 116-119, Year 2012
Publish dateMay 5, 2011 (structure data deposition date)
AuthorsDevore, N.M. / Scott, E.E.
External linksNature / PubMed:22266943
MethodsX-ray diffraction
Resolution2.4 - 2.6 Å
Structure data

PDB-3ruk:
Human Cytochrome P450 CYP17A1 in complex with Abiraterone
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-3swz:
Human Cytochrome P450 17A1 in complex with TOK-001
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-HEM:
PROTOPORPHYRIN IX CONTAINING FE

ChemComp-AER:
Abiraterone / medication*YM

ChemComp-HOH:
WATER

ChemComp-TOK:
(3alpha,8alpha)-17-(1H-benzimidazol-1-yl)androsta-5,16-dien-3-ol / inhibitor, antagonist*YM

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR / cytochrome P450 / CYP17A1 / P450 17A1 / monooxygenase / 17a-hydroxylase / 17 / 20-lyase / heme protein / cytochrome P450 oxidoreductase / Abiraterone / Zytiga / 17a-hydroxylation / membrane / microsome / endoplasmic reticulum / Galeterone / OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex / P450 / P450c17 / TOK-001 / VN/124-1

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