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TitleEnzymatic activity with an incomplete catalytic spine - insights from a comparative structural analysis of human CK2alpha and its paralogous isoform CK2alpha'
Journal, issue, pagesMol. Cell. Biochem., Vol. 356, Page 57-65, Year 2011
Publish dateApr 27, 2011 (structure data deposition date)
AuthorsBischoff, N. / Raaf, J. / Olsen, B. / Bretner, M. / Issinger, O.G. / Niefind, K.
External linksMol. Cell. Biochem. / PubMed:21739153
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-3rps:
Structure of human CK2alpha in complex with the ATP-competitive inhibitor 3-(4,5,6,7-tetrabromo-1H-benzotriazol-1-yl)propan-1-ol
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-4B0:
3-(4,5,6,7-tetrabromo-1H-benzotriazol-1-yl)propan-1-ol

ChemComp-SO4:
SULFATE ION

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / eukaryotic protein kinase fold / ATP CK2beta / Phosphorylation / cytoplasm nucleus / TRANSFERASE-TRANSFERASE INHIBITOR complex

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