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-Structure paper
Title | TMC310911, a Novel Human Immunodeficiency Virus Type 1 Protease Inhibitor, Shows In Vitro an Improved Resistance Profile and Higher Genetic Barrier to Resistance Compared with Current Protease Inhibitors. |
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Journal, issue, pages | Antimicrob. Agents Chemother., Vol. 55, Page 5723-5731, Year 2011 |
Publish date | Mar 17, 2011 (structure data deposition date) |
Authors | Dierynck, I. / Van Marck, H. / Van Ginderen, M. / Jonckers, T.H. / Nalam, M.N. / Schiffer, C.A. / Raoof, A. / Kraus, G. / Picchio, G. |
External links | Antimicrob. Agents Chemother. / PubMed:21896904 |
Methods | X-ray diffraction |
Resolution | 1.9 Å |
Structure data | PDB-3r4b: |
Chemicals | ChemComp-74T: ChemComp-PO4: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE/HYDROLASE INHIBITOR / drug resistance / drug design / protease inhibitors / AIDS / aspartyl protease / HYDROLASE-HYDROLASE INHIBITOR complex |