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TitleNovel and selective spiroindoline-based inhibitors of sky kinase.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 22, Page 190-193, Year 2012
Publish dateFeb 24, 2011 (structure data deposition date)
AuthorsPowell, N.A. / Kohrt, J.T. / Filipski, K.J. / Kaufman, M. / Sheehan, D. / Edmunds, J.E. / Delaney, A. / Wang, Y. / Bourbonais, F. / Lee, D.Y. ...Powell, N.A. / Kohrt, J.T. / Filipski, K.J. / Kaufman, M. / Sheehan, D. / Edmunds, J.E. / Delaney, A. / Wang, Y. / Bourbonais, F. / Lee, D.Y. / Schwende, F. / Sun, F. / McConnell, P. / Catana, C. / Chen, H. / Ohren, J. / Perrin, L.A.
External linksBioorg. Med. Chem. Lett. / PubMed:22119469
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-3qup:
Inhibitor bound structure of the kinase domain of the murine receptor tyrosine kinase TYRO3 (Sky)
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-LUN:
(5-fluoro-1H-indol-2-yl)[(3R)-1'-[(3R)-piperidin-3-yl]spiro[indole-3,3'-pyrrolidin]-1(2H)-yl]methanone

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
KeywordsTransferase/transferase inhibitor / protein kinase inhibitor / receptor tyrosine kinase / spirocycle / Kinase domain / Phosphotransfer / Gas6 ligand / Cytoplasmic surface / Transferase-transferase inhibitor complex

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