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TitleResolving the selectivity problem for p38 mitogen activated protein (MAP) Kinase-inhibitors: Development of new highly potent inhibitors of p38 MAP kinase with an outstanding selectivity profile
Journal, issue, pagesTo be Published
Publish dateFeb 23, 2011 (structure data deposition date)
AuthorsKarcher, S.C. / Fischer, S. / Schattel, V. / Romir, J. / Stehle, T. / Gruetter, C. / Rauh, D. / Laufer, S.A.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-3qud:
Human p38 MAP Kinase in Complex with 2-amino-phenylamino-benzophenone
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-BOG:
octyl beta-D-glucopyranoside / detergent*YM

ChemComp-N3F:
{4-[(2-aminophenyl)amino]phenyl}(phenyl)methanone

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Kinase Domain / Phosphate Transferase / Benzophenone Derivative

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