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TitleCrystal Structure of Human Cytochrome P450 2D6 with Prinomastat Bound.
Journal, issue, pagesJ. Biol. Chem., Vol. 287, Page 10834-10843, Year 2012
Publish dateFeb 3, 2011 (structure data deposition date)
AuthorsWang, A. / Savas, U. / Hsu, M.H. / Stout, C.D. / Johnson, E.F.
External linksJ. Biol. Chem. / PubMed:22308038
MethodsX-ray diffraction
Resolution2.85 Å
Structure data

PDB-3qm4:
Human Cytochrome P450 (CYP) 2D6 - Prinomastat Complex
Method: X-RAY DIFFRACTION / Resolution: 2.85 Å

Chemicals

ChemComp-HEM:
PROTOPORPHYRIN IX CONTAINING FE

ChemComp-PN0:
Prinomastat / inhibitor*YM

ChemComp-NI:
NICKEL (II) ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR / CYP2D6 / P450 2D6 / P450 / MONOOXYGENASE / Prinomastat / HEME / OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex

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