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-Structure paper
Title | Synthesis, activity, and structural analysis of novel alpha-hydroxytropolone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H. |
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Journal, issue, pages | J. Med. Chem., Vol. 54, Page 4462-4473, Year 2011 |
Publish date | Feb 2, 2011 (structure data deposition date) |
Authors | Chung, S. / Himmel, D.M. / Jiang, J.K. / Wojtak, K. / Bauman, J.D. / Rausch, J.W. / Wilson, J.A. / Beutler, J.A. / Thomas, C.J. / Arnold, E. / Le Grice, S.F. |
External links | J. Med. Chem. / PubMed:21568335 |
Methods | X-ray diffraction |
Resolution | 2.7 Å |
Structure data | PDB-3qlh: |
Chemicals | ChemComp-MNK: ChemComp-T27: ChemComp-MN: ChemComp-DMS: ChemComp-EDO: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE / HYDROLASE/INHIBITOR / RNase H Inhibitor / structure-based drug design / tropolone derivatives / divalent cation chelator / Non-nucleoside RT Inhibitor / HYDROLASE-INHIBITOR complex |