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TitlePyrrolo[1,2-f]triazines as JAK2 inhibitors: Achieving potency and selectivity for JAK2 over JAK3.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 21, Page 1425-1428, Year 2011
Publish dateDec 21, 2010 (structure data deposition date)
AuthorsHarikrishnan, L.S. / Kamau, M.G. / Wan, H. / Inghrim, J.A. / Zimmermann, K. / Sang, X. / Mastalerz, H.A. / Johnson, W.L. / Zhang, G. / Lombardo, L.J. ...Harikrishnan, L.S. / Kamau, M.G. / Wan, H. / Inghrim, J.A. / Zimmermann, K. / Sang, X. / Mastalerz, H.A. / Johnson, W.L. / Zhang, G. / Lombardo, L.J. / Poss, M.A. / Trainor, G.L. / Tokarski, J.S. / Lorenzi, M.V. / You, D. / Gottardis, M.M. / Baldwin, K.F. / Lippy, J. / Nirschl, D.S. / Qiu, R. / Miller, A.V. / Khan, J. / Sack, J.S. / Purandare, A.V.
External linksBioorg. Med. Chem. Lett. / PubMed:21282055
MethodsX-ray diffraction
Resolution2.5 Å
Structure data

PDB-3q32:
Structure of Janus kinase 2 with a pyrrolotriazine inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-J2I:
2-(2,6-difluoro-4-methoxyphenyl)-1-(4-{4-[(3-methyl-1H-pyrazol-5-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl}piperazin-1-yl)ethanone

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / ATP-binding / TRANSFERASE-TRANSFERASE INHIBITOR complex

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