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TitleStructural complex of sterol 14alpha-demethylase (CYP51) with 14alpha-methylenecyclopropyl-delta7-24, 25-dihydrolanosterol
Journal, issue, pagesJ. Lipid Res., Vol. 53, Page 311-320, Year 2012
Publish dateOct 16, 2010 (structure data deposition date)
AuthorsHargrove, T.Y. / Wawrzak, Z. / Liu, J. / Waterman, M.R. / Nes, W.D. / Lepesheva, G.I.
External linksJ. Lipid Res. / PubMed:22135275
MethodsX-ray diffraction
Resolution3 Å
Structure data

PDB-3p99:
Sterol 14alpha-demethylase (CYP51) from Trypanosoma brucei in complex with delta7-14alpha-methylene-cyclopropyl-dihydrolanosterol
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-HEM:
PROTOPORPHYRIN IX CONTAINING FE

ChemComp-LNP:
(3alpha,9beta,10alpha,13alpha)-30-cyclopropylidenelanost-7-en-3-ol

ChemComp-HOH:
WATER

Source
  • trypanosoma brucei (eukaryote)
KeywordsOXIDOREDUCTASE / Cytochrome P450 fold/sterol 14-alpha demethylase / CYP51 / monooxygenase / hemoprotein / sterol biosynthesis / cytochrome P450 reductase (CPR) / endoplasmic reticulum / membrane

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