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-Structure paper
Title | Identification and structure-activity relationship of 2-morpholino 6-(3-hydroxyphenyl) pyrimidines, a class of potent and selective PI3 kinase inhibitors. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 20, Page 6895-6898, Year 2010 |
Publish date | Oct 1, 2010 (structure data deposition date) |
Authors | Pecchi, S. / Renhowe, P.A. / Taylor, C. / Kaufman, S. / Merritt, H. / Wiesmann, M. / Shoemaker, K.R. / Knapp, M.S. / Ornelas, E. / Hendrickson, T.F. ...Pecchi, S. / Renhowe, P.A. / Taylor, C. / Kaufman, S. / Merritt, H. / Wiesmann, M. / Shoemaker, K.R. / Knapp, M.S. / Ornelas, E. / Hendrickson, T.F. / Fantl, W. / Voliva, C.F. |
External links | Bioorg. Med. Chem. Lett. / PubMed:21035331 |
Methods | X-ray diffraction |
Resolution | 3.2 Å |
Structure data | PDB-3p2b: |
Chemicals | ChemComp-P2B: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / PI3-kinase p110 subunit gamma / Transferase / Lipid Kinase / ATP Binding / TRANSFERASE-TRANSFERASE INHIBITOR complex |