+Search query
-Structure paper
Title | Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors. |
---|---|
Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 20, Page 7037-7041, Year 2010 |
Publish date | Sep 17, 2010 (structure data deposition date) |
Authors | Bencsik, J.R. / Xiao, D. / Blake, J.F. / Kallan, N.C. / Mitchell, I.S. / Spencer, K.L. / Xu, R. / Gloor, S.L. / Martinson, M. / Risom, T. ...Bencsik, J.R. / Xiao, D. / Blake, J.F. / Kallan, N.C. / Mitchell, I.S. / Spencer, K.L. / Xu, R. / Gloor, S.L. / Martinson, M. / Risom, T. / Woessner, R.D. / Dizon, F. / Wu, W.I. / Vigers, G.P. / Brandhuber, B.J. / Skelton, N.J. / Prior, W.W. / Murray, L.J. |
External links | Bioorg. Med. Chem. Lett. / PubMed:20971641 |
Methods | X-ray diffraction |
Resolution | 1.9 - 2.6 Å |
Structure data | PDB-3ow3: PDB-3ow4: |
Chemicals | ChemComp-SMY: ChemComp-HOH: |
Source |
|
Keywords | TRANSFERASE/TRANSFERASE inhibitor / cyclic-AMP dependent protein kinase / TRANSFERASE-TRANSFERASE inhibitor complex / SERINE-THREONINE KINASE / TRANSFERASE |