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Title | Contribution of the 80s loop of HIV-1 protease to the multidrug-resistance mechanism: crystallographic study of MDR769 HIV-1 protease variants. |
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Journal, issue, pages | Acta Crystallogr. ,Sect. D, Vol. 67, Page 524-532, Year 2011 |
Publish date | Sep 2, 2010 (structure data deposition date) |
Authors | Yedidi, R.S. / Proteasa, G. / Martinez, J.L. / Vickrey, J.F. / Martin, P.D. / Wawrzak, Z. / Liu, Z. / Kovari, I.A. / Kovari, L.C. |
External links | Acta Crystallogr. ,Sect. D / PubMed:21636892 |
Methods | X-ray diffraction |
Resolution | 1.71 - 2.25 Å |
Structure data | PDB-3oq7: PDB-3oqa: PDB-3oqd: PDB-3pj6: |
Chemicals | ChemComp-HOH: |
Source |
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Keywords | HYDROLASE / Protease / Alternate conformations of Pro81 / proline switch / Wide-open flaps / Expanded active site cavity |