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-Structure paper
Title | Design and Synthesis of Aminohydantoins as Potent and Selective Human beta-Secretase (BACE1) Inhibitors with Enhanced Brain Permeability |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 20, Page 6597-6605, Year 2010 |
Publish date | Aug 31, 2010 (structure data deposition date) |
Authors | Malamas, M.S. / Robichaud, A. / Erdei, J. / Quagliato, D. / Solvibile, W. / Zhou, P. / Morris, K. / Turner, J. / Wagner, E. / Fan, K. ...Malamas, M.S. / Robichaud, A. / Erdei, J. / Quagliato, D. / Solvibile, W. / Zhou, P. / Morris, K. / Turner, J. / Wagner, E. / Fan, K. / Olland, A. / Jacobsen, S. / Reinhart, P. / Riddell, D. / Pangalos, M. |
External links | Bioorg. Med. Chem. Lett. / PubMed:20880704 |
Methods | X-ray diffraction |
Resolution | 1.8 Å |
Structure data | PDB-3ooz: |
Chemicals | ChemComp-ZOO: ChemComp-HOH: |
Source |
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Keywords | hydrolase/hydrolase inhibitor / inhibitor / beta-secretase / protease / hydrolase-hydrolase inhibitor complex |