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Structure paper

TitleRAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.
Journal, issue, pagesNature, Vol. 464, Page 431-435, Year 2010
Publish dateAug 27, 2010 (structure data deposition date)
AuthorsHatzivassiliou, G. / Song, K. / Yen, I. / Brandhuber, B.J. / Anderson, D.J. / Alvarado, R. / Ludlam, M.J. / Stokoe, D. / Gloor, S.L. / Vigers, G. ...Hatzivassiliou, G. / Song, K. / Yen, I. / Brandhuber, B.J. / Anderson, D.J. / Alvarado, R. / Ludlam, M.J. / Stokoe, D. / Gloor, S.L. / Vigers, G. / Morales, T. / Aliagas, I. / Liu, B. / Sideris, S. / Hoeflich, K.P. / Jaiswal, B.S. / Seshagiri, S. / Koeppen, H. / Belvin, M. / Friedman, L.S. / Malek, S.
External linksNature / PubMed:20130576
MethodsX-ray diffraction
Resolution4 Å
Structure data

PDB-3omv:
Crystal structure of c-raf (raf-1)
Method: X-RAY DIFFRACTION / Resolution: 4 Å

Chemicals

ChemComp-SM5:
(1E)-5-(1-piperidin-4-yl-3-pyridin-4-yl-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / SERINE/THREONINE-PROTEIN KINASE

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