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TitleModulation of a GEF switch: Autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoREF
Journal, issue, pagesProtein Sci., Vol. 20, Page 107-117, Year 2011
Publish dateAug 11, 2010 (structure data deposition date)
AuthorsChen, Z. / Guo, L. / Sprang, S.R. / Sternweis, P.C.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.5 - 3.2 Å
Structure data

PDB-3odo:
Crystal Structure of the DH/PH Domains of p115-RhoGEF
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-3odw:
Crystal Structure of the Linker-DH/PH domains of p115-RhoGEF
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

PDB-3odx:
Crystal Structure of an N-terminally Truncated Linker-DH/PH Domains of p115-RhoGEF
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

PDB-3p6a:
Crystal Structure of the DH/PH domains of p115-RhoGEF (R399E mutant)
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / regulation of RhoA GTPase / RhoGEF / DH / PH / Rho

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