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-Structure paper
Title | Discovery of carmegliptin: A potent and long-acting dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 20, Page 1109-1113, Year 2010 |
Publish date | Dec 1, 2009 (structure data deposition date) |
![]() | Mattei, P. / Boehringer, M. / Di Giorgio, P. / Fischer, H. / Hennig, M. / Huwyler, J. / Kocer, B. / Kuhn, B. / Loeffler, B.M. / Macdonald, A. ...Mattei, P. / Boehringer, M. / Di Giorgio, P. / Fischer, H. / Hennig, M. / Huwyler, J. / Kocer, B. / Kuhn, B. / Loeffler, B.M. / Macdonald, A. / Narquizian, R. / Rauber, E. / Sebokova, E. / Sprecher, U. |
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Methods | X-ray diffraction |
Resolution | 2.4 - 2.7 Å |
Structure data | ![]() PDB-3kwf: ![]() PDB-3oc0: |
Chemicals | ![]() ChemComp-NAG: ![]() ChemComp-B1Q: ![]() ChemComp-HOH: ![]() ChemComp-B2Q: |
Source |
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![]() | HYDROLASE / Diabetes type II / Aminopeptidase / Cell membrane / Disulfide bond / Glycoprotein / Membrane / Protease / Secreted / Serine protease / Signal-anchor / Transmembrane |