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-Structure paper
| Title | Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model. |
|---|---|
| Journal, issue, pages | J. Biol. Chem., Vol. 285, Page 33054-33064, Year 2010 |
| Publish date | Aug 2, 2010 (structure data deposition date) |
 Authors | Booker, M.L. / Bastos, C.M. / Kramer, M.L. / Barker, R.H. / Skerlj, R. / Sidhu, A.B. / Deng, X. / Celatka, C. / Cortese, J.F. / Guerrero Bravo, J.E. ...Booker, M.L. / Bastos, C.M. / Kramer, M.L. / Barker, R.H. / Skerlj, R. / Sidhu, A.B. / Deng, X. / Celatka, C. / Cortese, J.F. / Guerrero Bravo, J.E. / Crespo Llado, K.N. / Serrano, A.E. / Angulo-Barturen, I. / Jimenez-Diaz, M.B. / Viera, S. / Garuti, H. / Wittlin, S. / Papastogiannidis, P. / Lin, J.W. / Janse, C.J. / Khan, S.M. / Duraisingh, M. / Coleman, B. / Goldsmith, E.J. / Phillips, M.A. / Munoz, B. / Wirth, D.F. / Klinger, J.D. / Wiegand, R. / Sybertz, E. |
 External links | J. Biol. Chem. / PubMed:20702404 |
| Methods | X-ray diffraction |
| Resolution | 2.3 Å |
| Structure data |  PDB-3o8a: |
| Chemicals |  ChemComp-O8A:  ChemComp-FMN:  ChemComp-ORO:  ChemComp-LDA:  ChemComp-HOH: |
| Source |
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 Keywords | OXIDOREDUCTASE / alpha beta fold / dihydroorotate dehydrogenase / Pyrimidine biosynthesis / Genz667348 / FAD / Flavoprotein / Mitochondrion inner membrane |
plasmodium falciparum (malaria parasite P. falciparum)