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TitleSalicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2).
Journal, issue, pagesJ. Med. Chem., Vol. 53, Page 2482-2493, Year 2010
Publish dateJul 28, 2010 (structure data deposition date)
AuthorsZhang, X. / He, Y. / Liu, S. / Yu, Z. / Jiang, Z.X. / Yang, Z. / Dong, Y. / Nabinger, S.C. / Wu, L. / Gunawan, A.M. ...Zhang, X. / He, Y. / Liu, S. / Yu, Z. / Jiang, Z.X. / Yang, Z. / Dong, Y. / Nabinger, S.C. / Wu, L. / Gunawan, A.M. / Wang, L. / Chan, R.J. / Zhang, Z.Y.
External linksJ. Med. Chem. / PubMed:20170098
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-3o5x:
Crystal structure of the oncogenic tyrosine phosphatase SHP2 complexed with a salicylic acid-based small molecule inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-JZG:
3-{1-[3-(biphenyl-4-ylamino)-3-oxopropyl]-1H-1,2,3-triazol-4-yl}-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / SHP2-IIB-08 complex / inhibitor / binding affinity / binding selectivity / receptor / Dephosphorylation

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