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-Structure paper
Title | Design, synthesis, biological evaluation and X-ray crystal structure of novel classical 6,5,6-tricyclic benzo[4,5]thieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors. |
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Journal, issue, pages | Bioorg. Med. Chem., Vol. 19, Page 3585-3594, Year 2011 |
Publish date | Jul 6, 2010 (structure data deposition date) |
Authors | Zhang, X. / Zhou, X. / Kisliuk, R.L. / Piraino, J. / Cody, V. / Gangjee, A. |
External links | Bioorg. Med. Chem. / PubMed:21550809 |
Methods | X-ray diffraction |
Resolution | 1.35 Å |
Structure data | PDB-3ntz: PDB-3nu0: |
Chemicals | ChemComp-3TZ: ChemComp-NDP: ChemComp-SO4: ChemComp-HOH: ChemComp-3TU: |
Source |
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Keywords | OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR / dihydrofolate reductase / cyclized inhibitors / OXIDOREDUCTASE hDHFR-263-NADPH / Oxidoreductase-Oxidoreductase Inhibitor complex / OXIDOREDUCTASE hDHFR-264-NADPH |