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Structure paper

TitleMolecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxen.
Journal, issue, pagesJ. Biol. Chem., Vol. 285, Page 34950-34959, Year 2010
Publish dateJul 2, 2010 (structure data deposition date)
AuthorsDuggan, K.C. / Walters, M.J. / Musee, J. / Harp, J.M. / Kiefer, J.R. / Oates, J.A. / Marnett, L.J.
External linksJ. Biol. Chem. / PubMed:20810665
MethodsX-ray diffraction
Resolution1.73 - 2.27 Å
Structure data

PDB-3nt1:
High resolution structure of naproxen:COX-2 complex.
Method: X-RAY DIFFRACTION / Resolution: 1.73 Å

PDB-3ntb:
Structure of 6-methylthio naproxen analog bound to mCOX-2.
Method: X-RAY DIFFRACTION / Resolution: 2.27 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-BOG:
octyl beta-D-glucopyranoside / detergent*YM

ChemComp-NPS:
(2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid / antiinflammatory*YM

ChemComp-HEM:
PROTOPORPHYRIN IX CONTAINING FE

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-T1N:
(2S)-2-[6-(methylsulfanyl)naphthalen-2-yl]propanoic acid

Source
  • mus musculus (house mouse)
KeywordsOXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR / Prostaglandin H2 Synthase / Cyclooxygenase-2 / Naproxen / OXIDOREDUCTASE / OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex / Cyclooxygeanse-2 / Naproxen analog

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