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| Title | Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: structure-activity relationship of the aryl region. |
|---|---|
| Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 20, Page 6034-6039, Year 2010 |
| Publish date | Jul 1, 2010 (structure data deposition date) |
 Authors | Probst, G.D. / Bowers, S. / Sealy, J.M. / Stupi, B. / Dressen, D. / Jagodzinska, B.M. / Aquino, J. / Gailunas, A. / Truong, A.P. / Tso, L. ...Probst, G.D. / Bowers, S. / Sealy, J.M. / Stupi, B. / Dressen, D. / Jagodzinska, B.M. / Aquino, J. / Gailunas, A. / Truong, A.P. / Tso, L. / Xu, Y.Z. / Hom, R.K. / John, V. / Tung, J.S. / Pleiss, M.A. / Tucker, J.A. / Konradi, A.W. / Sham, H.L. / Jagodzinski, J. / Toth, G. / Brecht, E. / Yao, N. / Pan, H. / Lin, M. / Artis, D.R. / Ruslim, L. / Bova, M.P. / Sinha, S. / Yednock, T.A. / Gauby, S. / Zmolek, W. / Quinn, K.P. / Sauer, J.M. |
 External links | Bioorg. Med. Chem. Lett. / PubMed:20822903 |
| Methods | X-ray diffraction |
| Resolution | 2.2 Å |
| Structure data |  PDB-3nsh: |
| Chemicals |  ChemComp-957:  ChemComp-HOH: |
| Source |
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 Keywords | HYDROLASE / MEMBRANE-ASSOCIATED ASPARTIC PROTEASE 2 / MEMAPSIN-2 / ASPARTYL PROTEASE 2 / ASP 2 / ASP2 / BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1 / BETA-SITE APP CLEAVING ENZYME 1 |
homo sapiens (human)