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TitleDiscovery of 6-(Aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxamides as Potent, Selective Dipeptidyl Peptidase-4 (DPP4) Inhibitors.
Journal, issue, pagesJ. Med. Chem., Vol. 53, Page 5620-5628, Year 2010
Publish dateJun 25, 2010 (structure data deposition date)
AuthorsMeng, W. / Brigance, R.P. / Chao, H.J. / Fura, A. / Harrity, T. / Marcinkeviciene, J. / O'Connor, S.P. / Tamura, J.K. / Xie, D. / Zhang, Y. ...Meng, W. / Brigance, R.P. / Chao, H.J. / Fura, A. / Harrity, T. / Marcinkeviciene, J. / O'Connor, S.P. / Tamura, J.K. / Xie, D. / Zhang, Y. / Klei, H.E. / Kish, K. / Weigelt, C.A. / Turdi, H. / Wang, A. / Zahler, R. / Kirby, M.S. / Hamann, L.G.
External linksJ. Med. Chem. / PubMed:20684603
MethodsX-ray diffraction
Resolution2.338 Å
Structure data

PDB-3nox:
Crystal structure of human DPP-IV in complex with Sa-(+)-(6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidin-2-yl)(morpholino)methanone
Method: X-RAY DIFFRACTION / Resolution: 2.338 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-6A5:
Sa-(+)-(6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidin-2-yl)(morpholino)methanone

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / EXOPEPTIDASE / ALPHA/BETA HYDROLASE FOLD / BETA BARREL / BETA PROPELLER / DPP4 / DIMER / PROTEIN:INHIBITOR COMPLEX / AMINOPEPTIDASE / GLYCOPROTEIN / MEMBRANE / PROTEASE / SECRETED / SERINE PROTEASE / SIGNAL-ANCHOR / TRANSMEMBRANE

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