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-Structure paper
Title | Improving the permeability of the hydroxyethylamine BACE-1 inhibitors: structure-activity relationship of P2' substituents. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 20, Page 4789-4794, Year 2010 |
Publish date | May 21, 2010 (structure data deposition date) |
Authors | Truong, A.P. / Probst, G.D. / Aquino, J. / Fang, L. / Brogley, L. / Sealy, J.M. / Hom, R.K. / Tucker, J.A. / John, V. / Tung, J.S. ...Truong, A.P. / Probst, G.D. / Aquino, J. / Fang, L. / Brogley, L. / Sealy, J.M. / Hom, R.K. / Tucker, J.A. / John, V. / Tung, J.S. / Pleiss, M.A. / Konradi, A.W. / Sham, H.L. / Dappen, M.S. / Toth, G. / Yao, N. / Brecht, E. / Pan, H. / Artis, D.R. / Ruslim, L. / Bova, M.P. / Sinha, S. / Yednock, T.A. / Zmolek, W. / Quinn, K.P. / Sauer, J.M. |
External links | Bioorg. Med. Chem. Lett. / PubMed:20634069 |
Methods | X-ray diffraction |
Resolution | 2.7 Å |
Structure data | PDB-3n4l: |
Chemicals | ChemComp-842: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE/HYDROLASE inhibitor / BACE / hydroxyethylamine / beta secretase / Alzheimer's disease / AD / beta-amyloid precursor protein / beta-APP / HYDROLASE-HYDROLASE inhibitor complex |