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| Title | Discovery of 4-(5-(Cyclopropylcarbamoyl)-2-Methylphenylamino)-5-Methyl-Npropylpyrrolo[1,2-F][1,2,4] Triazine-6-Carboxamide (Bms-582949), a Clinical P38 Map Kinase Inhibitor for the Treatment of Inflammatory Diseases |
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| Journal, issue, pages | J. Med. Chem., Vol. 53, Page 6629-6639, Year 2010 |
| Publish date | May 4, 2010 (structure data deposition date) |
 Authors | Liu, C. / Lin, J. / Wrobleski, S.T. / Lin, S. / Hynes, J. / Wu, H. / Dyckman, A.J. / Li, T. / Wityak, J. / Gillooly, K.M. ...Liu, C. / Lin, J. / Wrobleski, S.T. / Lin, S. / Hynes, J. / Wu, H. / Dyckman, A.J. / Li, T. / Wityak, J. / Gillooly, K.M. / Pitt, S. / Shen, D.R. / Zhang, R.F. / McIntyre, K.W. / Salter-Cid, L. / Shuster, D.J. / Zhang, H. / Marathe, P.H. / Doweyko, A.M. / Sack, J.S. / Kiefer, S.E. / Kish, K.F. / Newitt, J.A. / McKinnon, M. / Dodd, J.H. / Barrish, J.C. / Schieven, G.L. / Leftheris, K. |
 External links | J. Med. Chem. / PubMed:20804198 |
| Methods | X-ray diffraction |
| Resolution | 2 - 2.8 Å |
| Structure data |  PDB-3mvl:  PDB-3mvm: |
| Chemicals |  ChemComp-38P:  ChemComp-HOH:  ChemComp-39P: |
| Source |
|
 Keywords | TRANSFERASE / SERINE/THREONINE-PROTEIN KINASE / KINASE / P38 MAP KINASE / TRANSFERASE/TRANSFERASE INHIBITOR / TRANSFERASE-TRANSFERASE INHIBITOR complex |
homo sapiens (human)