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Structure paper

TitleInhibition of the function of class IIa HDACs by blocking their interaction with MEF2.
Journal, issue, pagesNucleic Acids Res., Vol. 40, Page 5378-5388, Year 2012
Publish dateMay 1, 2010 (structure data deposition date)
AuthorsJayathilaka, N. / Han, A. / Gaffney, K.J. / Dey, R. / Jarusiewicz, J.A. / Noridomi, K. / Philips, M.A. / Lei, X. / He, J. / Ye, J. ...Jayathilaka, N. / Han, A. / Gaffney, K.J. / Dey, R. / Jarusiewicz, J.A. / Noridomi, K. / Philips, M.A. / Lei, X. / He, J. / Ye, J. / Gao, T. / Petasis, N.A. / Chen, L.
External linksNucleic Acids Res. / PubMed:22396528
MethodsX-ray diffraction
Resolution2.434 Å
Structure data

PDB-3mu6:
Inhibiting the Binding of Class IIa Histone Deacetylases to Myocyte Enhancer Factor-2 by Small Molecules
Method: X-RAY DIFFRACTION / Resolution: 2.434 Å

Chemicals

ChemComp-BXL:
(3E)-N~8~-(2-aminophenyl)-N~1~-phenyloct-3-enediamide

Source
  • homo sapiens (human)
KeywordsDNA BINDING PROTEIN/DNA / MADS-box/MEF2 domain / transcription co-factors / protein-DNA complex / protein-protein docking / DNA BINDING PROTEIN-DNA complex

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