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-Structure paper
Title | Fragment-based discovery and optimization of BACE1 inhibitors. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 20, Page 5329-5333, Year 2010 |
Publish date | Apr 29, 2010 (structure data deposition date) |
Authors | Madden, J. / Dod, J.R. / Godemann, R. / Kraemer, J. / Smith, M. / Biniszkiewicz, M. / Hallett, D.J. / Barker, J. / Dyekjaer, J.D. / Hesterkamp, T. |
External links | Bioorg. Med. Chem. Lett. / PubMed:20656487 |
Methods | X-ray diffraction |
Resolution | 1.8 - 2.6 Å |
Structure data | PDB-3msj: PDB-3msk: PDB-3msl: PDB-3s2o: |
Chemicals | ChemComp-EV3: ChemComp-GOL: ChemComp-HOH: ChemComp-IOD: ChemComp-EV4: ChemComp-EV5: ChemComp-EV6: |
Source |
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Keywords | HYDROLASE/HYDROLASE INHIBITOR / PROTEASE / ALZHEIMER'S DISEASE / ASPARTIC PROTEASE / ASPARTYL PROTEASE / BASE / BETA-SECRETASE / GLYCOPROTEIN / HYDROLASE / MEMAPSIN 2 / AMYLOID PRECURSOR PROTEIN SECRETASES / ASPARTIC ENDOPEPTIDASES / FRAGMENT-BASED DRUG DESIGN / FLUORESCENCE POLARISATION / TRANSMEMBRANE / ZYMOGEN / HYDROLASE-HYDROLASE INHIBITOR complex |