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-Structure paper
Title | The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: The second clinical candidate having a shorter and favorable human half-life. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 20, Page 7159-7163, Year 2010 |
Publish date | Feb 1, 2010 (structure data deposition date) |
![]() | Wang, J.L. / Limburg, D. / Graneto, M.J. / Springer, J. / Hamper, J.R. / Liao, S. / Pawlitz, J.L. / Kurumbail, R.G. / Maziasz, T. / Talley, J.J. ...Wang, J.L. / Limburg, D. / Graneto, M.J. / Springer, J. / Hamper, J.R. / Liao, S. / Pawlitz, J.L. / Kurumbail, R.G. / Maziasz, T. / Talley, J.J. / Kiefer, J.R. / Carter, J. |
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Methods | X-ray diffraction |
Resolution | 2.19 - 2.8 Å |
Structure data | ![]() PDB-3ln0: ![]() PDB-3ln1: ![]() PDB-3mqe: ![]() PDB-3ntg: |
Chemicals | ![]() ChemComp-HEM: ![]() ChemComp-NAG: ![]() ChemComp-52B: ![]() ChemComp-BOG: ![]() ChemComp-HOH: ![]() ChemComp-CEL: ![]() ChemComp-416: ![]() ChemComp-D72: |
Source |
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![]() | OXIDOREDUCTASE / COX2 / COX-2 / PGH2S-2 / cyclooxygenase-2 / Dioxygenase / Disulfide bond / Endoplasmic reticulum / Fatty acid biosynthesis / Glycoprotein / Heme / Iron / Lipid synthesis / Membrane / Metal-binding / Microsome / Peroxidase / Phosphoprotein / Prostaglandin biosynthesis |