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-Structure paper
Title | Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies. |
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Journal, issue, pages | Bioorg. Med. Chem., Vol. 19, Page 3105-3119, Year 2011 |
Publish date | Apr 19, 2010 (structure data deposition date) |
![]() | Carta, F. / Garaj, V. / Maresca, A. / Wagner, J. / Avvaru, B.S. / Robbins, A.H. / Scozzafava, A. / McKenna, R. / Supuran, C.T. |
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Methods | X-ray diffraction |
Resolution | 1.5 Å |
Structure data | ![]() PDB-3mmf: ![]() PDB-3mna: |
Chemicals | ![]() ChemComp-ZN: ![]() ChemComp-D9H: ![]() ChemComp-GOL: ![]() ChemComp-HOH: ![]() ChemComp-DWH: |
Source |
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![]() | lyase/lyase inhibitor / zinc metalloenzyme / inhibitor / sulfonamide / metal-binding / triazine / LYASE / lyase-lyase inhibitor complex |