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Structure paper

TitleStructures of cytochrome P450 2B4 complexed with the antiplatelet drugs ticlopidine and clopidogrel.
Journal, issue, pagesBiochemistry, Vol. 49, Page 8709-8720, Year 2010
Publish dateNov 30, 2009 (structure data deposition date)
AuthorsGay, S.C. / Roberts, A.G. / Maekawa, K. / Talakad, J.C. / Hong, W.X. / Zhang, Q. / Stout, C.D. / Halpert, J.R.
External linksBiochemistry / PubMed:20815363
MethodsX-ray diffraction
Resolution2.67 - 3.1 Å
Structure data

PDB-3kw4:
Crystal structure of cytochrome 2B4 in complex with the anti-platelet drug ticlopidine
Method: X-RAY DIFFRACTION / Resolution: 2.67 Å

PDB-3me6:
Crystal structure of cytochrome 2B4 in complex with the anti-platelet drug clopidogrel
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

Chemicals

ChemComp-HEM:
PROTOPORPHYRIN IX CONTAINING FE

ChemComp-TIC:
ticlopidine / medication, inhibitor*YM

ChemComp-CM5:
5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE / detergent*YM

ChemComp-CH0:
2-{[(3alpha,5alpha,7alpha,8alpha,10alpha,12alpha,17alpha)-3,12-bis{2-[(4-O-alpha-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]ethoxy}cholan-7-yl]oxy}ethyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside

ChemComp-HOH:
WATER

ChemComp-CGE:
Clopidogrel / medication*YM

Source
  • oryctolagus cuniculus (rabbit)
KeywordsOXIDOREDUCTASE / P450 / cytochrome P450 2B4 / monooxygenase / membrane protein / CYP 2B4 / CYP LM2 / Endoplasmic reticulum / Heme / Iron / Membrane / Metal-binding / Microsome

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