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TitleStructure-based design and synthesis of pyrrole derivatives as MEK inhibitors.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 20, Page 4156-4158, Year 2010
Publish dateMar 25, 2010 (structure data deposition date)
AuthorsWallace, M.B. / Adams, M.E. / Kanouni, T. / Mol, C.D. / Dougan, D.R. / Feher, V.A. / O'Connell, S.M. / Shi, L. / Halkowycz, P. / Dong, Q.
External linksBioorg. Med. Chem. Lett. / PubMed:20621728
MethodsX-ray diffraction
Resolution2.6 Å
Structure data

PDB-3mbl:
Crystal Structure of the human mitogen-activated protein kinase kinase 1 (MEK 1) in complex with ligand and MgADP
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-ADP:
ADENOSINE-5'-DIPHOSPHATE / ADP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-LSG:
5-acetyl-2-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)-1-methyl-1H-pyrrole-3-carboxamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Kinase inhibitor

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