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Structure paper

TitleX-ray structure and mechanism of RNA polymerase II stalled at an antineoplastic monofunctional platinum-DNA adduct.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 107, Page 9584-9589, Year 2010
Publish dateMar 10, 2010 (structure data deposition date)
AuthorsWang, D. / Zhu, G. / Huang, X. / Lippard, S.J.
External linksProc. Natl. Acad. Sci. USA / PubMed:20448203
MethodsX-ray diffraction
Resolution3.18 - 3.57 Å
Structure data

PDB-3m3y:
RNA polymerase II elongation complex C
Method: X-RAY DIFFRACTION / Resolution: 3.18 Å

PDB-3m4o:
RNA polymerase II elongation complex B
Method: X-RAY DIFFRACTION / Resolution: 3.57 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-C7P:
cis-diammine(pyridine)chloroplatinum(II)

Source
  • saccharomyces cerevisiae (brewer's yeast)
KeywordsTRANSFERASE/DNA-RNA HYBRID / TRANSCRIPTION / MRNA / MULTIPROTEIN COMPLEX / MOLECULAR MACHINE / DNA / DNA Damage / Cancer / Platinum Drug / DNA-binding / DNA-directed RNA polymerase / Isopeptide bond / Magnesium / Metal-binding / Nucleotidyltransferase / Nucleus / Phosphoprotein / Transferase / Ubl conjugation / Zinc / Zinc-finger / Polymorphism / Cytoplasm / DNA repair / TRANSFERASE-DNA-RNA HYBRID complex

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