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TitleWater-soluble PDE4 inhibitors for the treatment of dry eye.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 20, Page 2928-2932, Year 2010
Publish dateFeb 26, 2010 (structure data deposition date)
AuthorsGovek, S.P. / Oshiro, G. / Anzola, J.V. / Beauregard, C. / Chen, J. / Coyle, A.R. / Gamache, D.A. / Hellberg, M.R. / Hsien, J.N. / Lerch, J.M. ...Govek, S.P. / Oshiro, G. / Anzola, J.V. / Beauregard, C. / Chen, J. / Coyle, A.R. / Gamache, D.A. / Hellberg, M.R. / Hsien, J.N. / Lerch, J.M. / Liao, J.C. / Malecha, J.W. / Staszewski, L.M. / Thomas, D.J. / Yanni, J.M. / Noble, S.A. / Shiau, A.K.
External linksBioorg. Med. Chem. Lett. / PubMed:20378348
MethodsX-ray diffraction
Resolution2.6 Å
Structure data

PDB-3ly2:
Catalytic Domain of Human Phosphodiesterase 4B in Complex with A Coumarin-Based Inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-Z72:
8-(cyclopentyloxy)-4-[(3,5-dichloropyridin-4-yl)amino]-7-methoxy-2H-chromen-2-one

ChemComp-ZN:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE/HYDROLASE INHIBITOR / PDE4B / COUMARIN / INHIBITOR / HYDROLASE / Metal-binding / HYDROLASE-HYDROLASE INHIBITOR complex

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