+Search query
-Structure paper
Title | Discovery of imidazo[1,5-a]pyrido[3,2-e]pyrazines as a new class of phosphodiesterase 10A inhibitiors. |
---|---|
Journal, issue, pages | J. Med. Chem., Vol. 53, Page 4399-4411, Year 2010 |
Publish date | Feb 25, 2010 (structure data deposition date) |
![]() | Hofgen, N. / Stange, H. / Schindler, R. / Lankau, H.J. / Grunwald, C. / Langen, B. / Egerland, U. / Tremmel, P. / Pangalos, M.N. / Marquis, K.L. ...Hofgen, N. / Stange, H. / Schindler, R. / Lankau, H.J. / Grunwald, C. / Langen, B. / Egerland, U. / Tremmel, P. / Pangalos, M.N. / Marquis, K.L. / Hage, T. / Harrison, B.L. / Malamas, M.S. / Brandon, N.J. / Kronbach, T. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 2.3 Å |
Structure data | ![]() PDB-3lxg: |
Chemicals | ![]() ChemComp-Z73: ![]() ChemComp-ZN: ![]() ChemComp-MG: ![]() ChemComp-HOH: |
Source |
|
![]() | HYDROLASE / PHOSPHODIESTERASE 10A; CATALYTIC DOMAIN / Allosteric enzyme / cAMP / cAMP-binding / cGMP / cGMP-binding / Metal-binding / Nucleotide-binding |